Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer
GSE279751 · GEO

TL;DR — A 335.6 MB multi-omics / other deposit (GSE279751, 2 file(s), liver) in the MASLD / NAFLD / NASH data lake. large (10 GB).

0. Summary

Biological premise.

This deposit is included in the MASLD (metabolic dysfunction-associated steatotic liver disease) data lake for the following curated reason: large (10 GB). No free-text abstract was exposed by the repository API; the measured file inventory below is authoritative for what the deposit contains.

Every file in this dataset is a multi-omics / other readout relevant to MASLD / non-alcoholic fatty liver disease (NAFLD) / non-alcoholic steatohepatitis (NASH), landed from GEO.

Assay and processing.

Modality: multi-omics / other (repository subtype: ATAC/ChIP). Tier-1 (must-have) for this modality = the rawest deposited measurement table + a sample/condition design table; Tier-2 (recommended) = annotation/feature table, author result tables; Tier-3 (optional / raw) = raw signal + reference + tool versions. The Completeness line in each dataset block below states, measured from the landed files, which tiers are present.

Sources.

GSE279751 — GEO deposit (large (10 GB)).
PMIDs: none recorded in the index for this deposit.


Disease	MASLD / NAFLD / NASH
Assay / modality	multi-omics / other — ATAC/ChIP
Organisms	unspecified
Repository	GEO — NCBI GEO FTP
Accession	GSE279751
Access	Public (open); files mirrored in this dataset's `input/` folder.
Number of studies	1
Number of files	2
Total size	335,648,063 bytes (≈ 335.6 MB)

1. Datasets — sample sources, protocols, experiment design and metadata

Landed sources at a glance.

Source	Access	Files
GEO	public / OPEN-processed	2

The deposit at a glance.

Accession	Description	Organism	Samples	Scale
GSE279751	large (10 GB)	unspecified	n/a	2 files · 335.6 MB

GSE279751 — Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

GEO record · 2 files · 335.6 MB

Sample source. unspecified material; MASLD/NAFLD/NASH context (large (10 GB)).
Samples and retention. Sample count not declared in the repository index; see the per-sample metadata file(s) listed below.
Experiment design. Repository subtype: ATAC/ChIP; disease context MASLD/NAFLD/NASH.
Metadata available. See the annotated file table below; per-sample metadata ships in the ISA-Tab / SDRF / metadata file(s) where present.
Files (annotated).

File What it is
GSE279751_RAW.tar GEO per-sample raw supplementary bundle (tar of per-GSM files)
filelist.txt Text data / metadata table (21 data rows × 5 cols)
How this experiment became a dataset. GSE279751 resolved via the GEO record API → 2 open file(s) fetched into this dataset's input/ folder → sizes verified on disk (335,648,063 bytes (≈ 335.6 MB)).
Completeness (multi-omics / other). Present: primary data table(s). (Tiers per the matching modality skill; assessment measured from landed filenames/headers.)

File	What it is
`GSE279751_RAW.tar`	GEO per-sample raw supplementary bundle (tar of per-GSM files)
`filelist.txt`	Text data / metadata table (21 data rows × 5 cols)

2. Analyses this atlas supports

Reuse the processed tables. Start from GSE279751_RAW.tar; combine with the per-sample metadata file to reproduce the deposit's headline numbers.
Cross-cohort MASLD integration. Combine this deposit (GSE279751) with other liver/MASLD datasets in the lake sharing the same modality for meta-analysis.

Reproduce. All files are in this dataset's input/ folder; the source of record is GSE279751 (https://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279751/suppl/). Re-fetch with the MASLD crawler (masld_download_pass.py --only GSE279751); sizes are verified on disk and recorded in this dataset's metadata.json.

Citation

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer. GEO accession GSE279751. https://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279751/suppl/